Early ADMET

In collaboration with Apredica (Watertown, MA), ProXyChem can provide the following services:

• In Vitro ADME Screens
• Solubility
• Test article stability
• Cell-based toxicity (HepG2, NIH3T3, other)
• Metabolic
• Stability and interspecies comparison
• rCYP450 inhibition
• Caco-2 permeability
• Protein binding
• Cell-based toxicity
• CYP identification: metabolite profile
• In Vivo Bioanalysis (Non-GLP)
• Rapid PK for candidate selection
• PK parameter calculations
• Bioanalytical method development
• Tissue Extraction Method Development
• Specialty Services
• Hemolysis
• hERG cardiac toxicity
• Intranasal and lung